Clinical Significance of HRNR Expression in Patients With Stage II/III Gastric Cancer After Curative Gastrectomy
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View abstract on PubMed
Summary
This summary is machine-generated.Hornerin (HRNR) is elevated in gastric cancer (GC) tissues. High HRNR expression in patients with Stage II/III GC indicates a poorer prognosis and shorter survival after surgery.
Area Of Science
- Oncology
- Molecular Biology
- Cancer Research
Background
- The role of hornerin (HRNR), an S-100 protein family member, in gastric cancer (GC) remains unclear.
- Investigating HRNR's function is crucial for understanding GC progression.
Purpose Of The Study
- To determine the clinical significance of HRNR expression in gastric cancer tissues.
- To evaluate HRNR as a prognostic marker in patients with pathological Stage II/III GC.
Main Methods
- Quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure HRNR expression in 253 GC tissues and adjacent normal mucosa.
- Clinicopathological features and overall survival (OS) were analyzed in relation to HRNR expression levels.
Main Results
- HRNR expression was significantly higher in GC tissues compared to normal tissues.
- High HRNR expression correlated with poorer 5-year overall survival (53.6% vs. 74.9%, p=0.004).
- Multivariate analysis identified high HRNR expression as an independent predictor of poor OS (HR=1.534, p=0.011).
Conclusions
- HRNR expression in gastric cancer tissue is a potential prognostic marker.
- Elevated HRNR levels may indicate a worse outcome for patients with Stage II/III GC undergoing curative resection.
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