Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...

Urinary Tract Infection II: Pathophysiology

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...

Urinary Tract Infection I: Introduction

Urinary Tract Infection I: Introduction

Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...

Urine Studies II: Urine Culture and Sensitivity Test

Urine Studies II: Urine Culture and Sensitivity Test

A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pelvic Health.

The Journal of urology·2026

Same author

Beyond the bladder: incontinence-specific, physical, and psychological contributors to sexual function in women with urinary incontinence.

The journal of sexual medicine·2026

Same author

Patient-reported outcomes in pelvic organ prolapse repair: the missing information needed to inform our understanding of what matters most to patients.

Gynecology and pelvic medicine·2026

Same author

Pelvic Health.

The Journal of urology·2026

Same author

Pelvic Health.

The Journal of urology·2026

Same author

Reply: Updates to Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline (2025).

The Journal of urology·2026

Search research articles

Related Experiment Video

Updated: Jun 11, 2025

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

Manipulating the Gut Microbiome in Urinary Tract Infection-Prone Patients.

Rahul Dutta¹, Lynn Stothers¹, A Lenore Ackerman¹

¹Division of Urogynecology and Reconstructive Pelvic Surgery, David Geffen School of Medicine at UCLA, Box 951738, Los Angeles, CA 90095-1738, USA.

The Urologic Clinics of North America

|September 30, 2024

Summary

This summary is machine-generated.

Antibiotics for urinary tract infections can disrupt the gut microbiome, increasing recurrence risk. Nonantibiotic strategies like probiotics and fecal transplants offer promising alternatives to restore gut health and prevent repeat infections.

Keywords:

Cranberry Fecal microbiota transplant Gut dysbiosis Microbiome Probiotics Short chain fatty acids Urinary tract infection

More Related Videos

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

Published on: April 16, 2019

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Published on: December 4, 2020

Related Experiment Videos

Last Updated: Jun 11, 2025

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

Published on: April 16, 2019

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Published on: December 4, 2020

Area of Science:

Microbiome research
Infectious disease

Background:

Antibiotics are standard for urinary tract infections (UTIs) but can cause recurrent infections.
Recurrent UTIs are linked to gut microbiome disruption, promoting pathogen growth and reducing host resistance.

Purpose of the Study:

To explore nonantibiotic methods for managing gut microbiome disturbances caused by antibiotic use.
To identify strategies that can reverse antibiotic-induced systemic changes and decrease UTI recurrence.

Main Methods:

Review of nonantibiotic interventions targeting the gut microbiome.
Discussion of dietary approaches, including cranberry supplementation.
Analysis of probiotic administration and fecal microbiota transplantation.

Main Results:

Gut microbiome manipulation shows potential in mitigating antibiotic side effects.
Cranberry, probiotics, and FMT may help restore microbial balance and enhance host defense.
These approaches aim to break the cycle of recurrent UTIs.

Conclusions:

Nonantibiotic strategies offer a promising avenue for managing recurrent UTIs.
Targeting the gut microbiome can reverse negative systemic effects of antibiotics.
Further research into microbiome modulation is crucial for UTI prevention.