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MicroRNAs as commonly expressed biomarkers for sarcopenia and frailty: A systematic review

Hyung Eun Shin1, Jae Young Jang2, Heeeun Jung3

  • 1Department of Orthopaedics, Emory Musculoskeletal Institute, Emory University School of Medicine, Atlanta, GA 30329, USA; Department of Health Sciences and Technology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.

Experimental Gerontology
|September 30, 2024
PubMed
Abstract

Insights

Shared microRNAs (miRNAs) show consistent expression patterns in both sarcopenia and frailty. These findings suggest miRNAs as potential biomarkers for early diagnosis and progression monitoring of these conditions.

Area of Science:

  • Biochemistry
  • Gerontology
  • Molecular Biology

Background:

  • Coexistent sarcopenia and frailty present a greater health risk than either condition alone.
  • Understanding the mechanisms underlying combined sarcopenia and frailty is crucial.
  • Noncoding RNAs are emerging as potential biomarkers for sarcopenia and frailty.

Conclusions:

  • Shared microRNAs (miRNAs) with consistent expression patterns hold promise as biomarkers.
  • These miRNAs can aid in the early diagnosis of sarcopenia and frailty.
  • Consistent miRNA expression can also assist in assessing disease progression.
Keywords:
BiomarkerFrailtyNoncoding RNASarcopeniamiRNA

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