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DAMPs in immunosenescence and cancer

Fangquan Chen1, Hu Tang1, Xiutao Cai1

  • 1DAMP Laboratory, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510150, China.

Seminars in Cancer Biology
|September 30, 2024
PubMed

Insights

Damage-associated molecular patterns (DAMPs) trigger sterile inflammation, impacting tissue repair, aging, and cancer. Targeting DAMPs offers therapeutic potential for age-related diseases and cancer immunity.

Area of Science:

  • Immunology
  • Cell Biology
  • Gerontology

Background:

  • Damage-associated molecular patterns (DAMPs) are endogenous molecules released during cellular injury or stress.
  • DAMPs interact with innate immune receptors, initiating sterile inflammation crucial for tissue repair but also implicated in pathology.
  • Chronic inflammation from DAMPs accelerates immunosenescence and influences age-related cancers.

Purpose of the Study:

  • To review immunosenescence and its role in age-related cancers.
  • To investigate DAMP types, release mechanisms, and immune activation pathways.
  • To explore therapeutic strategies targeting DAMPs in age-related diseases.

Main Methods:

  • Literature review of immunosenescence, DAMPs, and age-related diseases.
  • Analysis of DAMP release mechanisms and immune signaling pathways.
  • Examination of therapeutic interventions targeting DAMPs.

Main Results:

  • DAMPs are key mediators of sterile inflammation, linking cellular damage to immune responses.
  • DAMP-induced inflammation exacerbates immunosenescence and affects cancer progression and immunity.
  • Understanding DAMP signaling is vital for immune regulation and therapeutic development.

Conclusions:

  • DAMPs play a critical role at the intersection of aging and cancer.
  • Targeting DAMPs presents a promising avenue for treating age-related diseases and modulating anti-tumor immunity.
  • Further research into DAMP signal transduction can yield novel therapeutic strategies.
Keywords:
AgingCancerCell deathDAMPsImmunosenescence

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