Exposure of cumulative atherogenic index of plasma and the development of prediabetes in middle-aged and elderly individuals: evidence from the CHARLS cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.Cumulative atherogenic index of plasma (CumAIP) significantly impacts prediabetes progression. High CumAIP increases diabetes risk and hinders regression to normal glucose levels, highlighting the importance of monitoring AIP.
Area Of Science
- Cardiovascular Disease Epidemiology
- Metabolic Syndrome Research
- Diabetes Pathophysiology
Background
- The relationship between dynamic atherosclerosis changes and prediabetes development is not well understood.
- Atherosclerosis progression may influence metabolic health and glycemic control.
Purpose Of The Study
- To investigate the association between cumulative atherogenic index of plasma (CumAIP) exposure and prediabetes development.
- To analyze the impact of CumAIP on prediabetes progression and regression in middle-aged and elderly individuals.
Main Methods
- Analysis of 2,939 prediabetic participants from the China Health and Retirement Longitudinal Study (CHARLS).
- Calculation of CumAIP based on average AIP values and exposure duration.
- Utilized multivariable Cox regression and restricted cubic spline (RCS) regression for association analysis.
Main Results
- A 3-year follow-up showed 15.21% progression to diabetes and 22.12% regression to normal fasting glucose (NFG).
- Higher CumAIP quartiles correlated with increased diabetes progression and decreased NFG regression.
- High CumAIP exposure demonstrated a significant positive linear association with prediabetes progression and negative with regression.
Conclusions
- Cumulative atherogenic index of plasma (CumAIP) is strongly linked to prediabetes outcomes.
- Elevated CumAIP exacerbates prediabetes progression and impedes regression to normal glucose levels.
- Monitoring and managing AIP levels may be crucial for preventing worsening glycemic control.
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