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Related Experiment Video

Updated: Jun 11, 2025

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

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Published on: May 19, 2015

Facilitating Thought Progression to Reduce Depressive Symptoms: Randomized Controlled Trial.

Shai-Lee Yatziv¹, Paola Pedrelli^2,3, Shira Baror¹

¹The Leslie and Susan Gonda Brain Science Center, Ramat-Gan, Israel.

Journal of Medical Internet Research

|October 1, 2024

Summary

A novel gamified app effectively reduced depressive symptoms by facilitating thought progression. This digital intervention offers a promising, accessible complement to traditional depression treatments.

Keywords:

FTP RCT app cognitive neuroscience depression depression symptoms depressive disorder digital health effectiveness facilitating thought progression gamification mobile phone randomized controlled trial web-based platforms

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Last Updated: Jun 11, 2025

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Published on: May 19, 2015

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Published on: August 11, 2015

Area of Science:

Digital Health
Psychiatry
Computational Psychology

Background:

Major depressive disorder (MDD) prevalence necessitates accessible interventions.
Digital health platforms show potential for addressing gaps in mental healthcare.
Targeting ruminative thought, a key depression symptom, is crucial for effective treatment.

Purpose of the Study:

To evaluate the efficacy of a novel digital intervention for reducing depressive symptoms.
The intervention is a gamified app designed to promote thought progression through creative and associative thinking patterns.

Main Methods:

A randomized clinical trial compared a gamified app intervention group (n=74) with a waitlist control group (n=27) over 8 weeks.
Depression severity was assessed using Montgomery-Åsberg Depression Rating Scale (MADRS), Patient Health Questionnaire-9 (PHQ-9), and other clinical questionnaires.
Secondary measures included anxiety, positive affect, anhedonia, and quality of life assessments.

Main Results:

The intervention group showed significantly greater and faster improvement in depressive symptoms compared to the control group (MADRS difference: -7.01 points, P<.001, Cohen d=0.67).
Symptom improvement persisted up to 4 weeks post-trial.
Participants expressed high interest in continued app usage.

Conclusions:

A gamified app facilitating thought progression significantly improves depressive symptoms.
This digital approach offers an innovative, accessible, and potentially impactful adjunct to conventional depression therapies.
The app may enhance the lives of individuals with depression and anxiety.