Autoimmune Metaplastic Atrophic Gastritis (AMAG): Regional Demographics and Their Effect on Prevalence

Area of Science:

• Gastroenterology
• Immunology
• Epidemiology

Background:

• Autoimmune metaplastic atrophic gastritis (AMAG) is an immune-mediated condition damaging oxyntic cells, leading to iron deficiency and pernicious anemia.
• The prevailing view identifies AMAG predominantly in older, non-Hispanic White women.
• This study challenges the traditional demographic profile of AMAG.

Purpose of the Study:

• To investigate the prevalence of AMAG in a Hispanic-enriched population.
• To compare AMAG incidence in Florida's Hispanic population against non-Hispanic populations.
• To assess if AMAG demographics differ from current medical understanding.

Main Methods:

• Prospective collection of 1708 gastric biopsies from 1692 patients over one year at University of Miami Hospitals/Jackson Health Systems.
• Analysis of patient demographics, including self-identified race and ethnicity.
• Comparison of Florida data with previously reported data from Baltimore, a population with fewer Hispanic individuals.

Main Results:

• AMAG was identified in 79 out of 1692 patients (4.6%) in the Florida cohort.
• The demographic profile mirrored the Florida population, with 76% of AMAG patients being Hispanic.
• The prevalence of AMAG in Florida (4.6%) was significantly higher than in Baltimore (1.1%, p < .00001), particularly in Hispanic patients.

Conclusions:

• AMAG prevalence is significantly higher in Hispanic populations compared to non-Hispanic populations.
• The findings suggest AMAG is underrecognized in Hispanic individuals.
• Increased awareness of AMAG in diverse populations is crucial for timely diagnosis and management.