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Introduction
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  11. Impact Of Preoperative Inflammatory And Nutritional Markers On The Prognosis Of Patients With Peritoneal Metastasis Of Colorectal Cancer.

Impact of preoperative inflammatory and nutritional markers on the prognosis of patients with peritoneal metastasis of colorectal cancer.

Zhi-Jie Wu1,2,3, Bing Lan1,2,3, Jian Luo1,2,3

  • 1Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China.

World Journal of Gastrointestinal Oncology
|October 1, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

High neutrophil-to-lymphocyte ratio (NLR) and low hemoglobin (Hb) predict poor prognosis in colorectal cancer with peritoneal metastasis (CRC-PM). A developed nomogram accurately predicts overall survival (OS) for CRC-PM patients.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Cancer Prognostics

Background:

  • Identifying patients with colorectal cancer peritoneal metastasis (CRC-PM) who benefit from surgery is critical.
  • Inflammatory and nutritional markers are key in cancer development and metastasis.

Purpose of the Study:

  • To investigate the prognostic association of preoperative inflammatory and nutritional markers in patients with CRC-PM.

Main Methods:

  • Evaluated 133 CRC-PM patients (July 2012-July 2018).
  • Assessed demographics, overall survival (OS), and preoperative inflammatory/nutritional markers.
  • Utilized Kaplan-Meier method and log-rank test for survival analysis.

Main Results:

  • High neutrophil-to-lymphocyte ratio (NLR) correlated with significantly lower median OS (7.9 months vs. 25.4 months).
Keywords:
Colorectal cancerHemoglobinNeutrophil-to-lymphocyte ratioOverall survival

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  • Low hemoglobin (Hb) was associated with shorter median OS (6.3 months vs. 18.5 months).
  • A nomogram incorporating age, carbohydrate antigen 199, NLR, Hb, and peritoneal cancer index showed good predictive capacity (C-index: 0.715).

    • Conclusions:

    • High NLR and low Hb are independent predictors of poor prognosis in CRC-PM.
    • The developed nomogram accurately predicts OS in CRC-PM patients.
    • The nomogram serves as a valuable prognostic tool for this patient group.
    Peritoneal metastasis
    Prognosis