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Related Concept Videos

Tissue Homogenization and Cell Lysis01:32

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Tissue homogenization involves disintegrating tissue architecture and lysing cells, and is an early step in isolating and analyzing cellular components. The method used for homogenization depends on the sample type, the amount of sample available, the analyte to be obtained, and the sensitivity of the method. These methods are broadly classified as mechanical and non-mechanical methods.
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Related Experiment Video

Updated: May 7, 2026

Imaging Cleared Intact Biological Systems at a Cellular Level by 3DISCO
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T-CLEARE: a pilot community-driven tissue clearing protocol repository.

Kurt R Weiss1, Jan Huisken1, Neda Khanjani2

  • 1Morgridge Institute for Research, Madison, WI, United States.

Frontiers in Bioengineering and Biotechnology
|October 1, 2024
PubMed
Summary
This summary is machine-generated.

Choosing a tissue clearing protocol is difficult due to many options and variable results. We created T-CLEARE, a free repository of tissue clearing protocols, to share community evaluations and modifications for better experimental outcomes.

Keywords:
databasemicroscopyneurosciencetissue clearingtissue clearing methods

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Area of Science:

  • Biological imaging
  • Histology
  • Microscopy

Background:

  • Tissue clearing is crucial for 3D imaging but selecting protocols is challenging.
  • Existing protocols vary in performance (speed, cost, stability, quenching) and require optimization.
  • Results can differ significantly based on tissue type and antibodies used.

Purpose of the Study:

  • To develop a centralized, accessible resource for tissue clearing protocols.
  • To facilitate the sharing of protocol evaluations, modifications, and negative results.
  • To aid researchers in selecting optimal tissue clearing methods for specific applications.

Main Methods:

  • Development of a novel, freely available repository named T-CLEARE.
  • Incorporation of community feedback via an open survey.
  • Collection of detailed protocol information, including modifications and performance issues.

Main Results:

  • T-CLEARE provides a platform for sharing diverse tissue clearing protocol data.
  • The repository captures practical insights beyond published literature.
  • Community contributions highlight protocol successes and failures across various contexts.

Conclusions:

  • T-CLEARE aims to streamline the selection and implementation of tissue clearing protocols.
  • The repository empowers researchers to leverage collective knowledge for improved experimental design.
  • Facilitating data sharing can accelerate advancements in 3D tissue imaging.