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HER2-targeted therapies for HER2-positive early-stage breast cancer: present and future

Luying Xu1,2, Yuxin Xie1,2, Qiheng Gou3

  • 1Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Pharmacology
|October 1, 2024
PubMed

Insights

HER2-targeted drugs improve outcomes for HER2-positive early-stage breast cancer (HER2+ EBC). This review details their mechanisms, resistance, and clinical use in HER2+ EBC patients.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Breast cancer (BC) is a leading cause of cancer death globally.
  • HER2 overexpression occurs in 20-30% of BC patients.
  • HER2-targeted therapies have improved outcomes for HER2-positive early-stage breast cancer (HER2+ EBC).

Purpose of the Study:

  • To systematically review HER2-targeted drugs for HER2+ EBC.
  • To summarize mechanisms, resistance, therapeutic modalities, and safety.
  • To enhance clinical understanding and application of these therapies.

Main Methods:

  • Systematic literature review.
  • Analysis of HER2-targeted drug mechanisms.
  • Evaluation of therapeutic strategies and safety profiles.

Main Results:

  • HER2-targeted drugs (mAbs, TKIs, ADCs) enhance treatment efficacy.
  • These therapies improve operation and remission rates.
  • Reduced postoperative recurrence risk observed in HER2+ EBC patients.

Conclusions:

  • HER2-targeted drugs are crucial for managing HER2+ EBC.
  • Understanding drug mechanisms and resistance is key for optimal use.
  • This review provides comprehensive insights for clinical practice.
Keywords:
HER2-positive breast canceradjuvant therapyearly-stage breast cancerneoadjuvant therapytargeted therapy

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