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Updated: Jun 11, 2025

Synthesis of Decellularized Cartilage Extracellular Matrix Hydrogels
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Decellularised extracellular matrix-based injectable hydrogels for tissue engineering applications.

Wan-Ying Guo1, Wei-Huang Wang1, Pei-Yao Xu1,2

  • 1Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, Fujian Province, China.

Biomaterials Translational
|October 1, 2024
PubMed
Summary

Decellularised extracellular matrix (dECM) injectable hydrogels offer biocompatibility for tissue engineering. This review explores their preparation, properties, and applications in regenerative medicine.

Keywords:
decellularisation methodsdecellularised extracellular matrixinjectable hydrogelstissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Decellularised extracellular matrix (dECM) is a biocompatible and malleable biomaterial derived from natural tissues.
  • Injectable hydrogels offer advantages in tissue engineering due to their fluidity and in vivo gelation capabilities.
  • dECM-based injectable hydrogels show promise for complex organ structures and tissue repair.

Purpose of the Study:

  • To review recent advances in decellularised extracellular matrix (dECM)-based injectable hydrogels.
  • To summarize preparation methods and evaluate the properties of these hydrogels.
  • To explore the applications and future prospects of dECM hydrogels in tissue engineering.

Main Methods:

  • Literature review of research on dECM-based injectable hydrogels.
  • Analysis of preparation techniques and property evaluations.
  • Compilation of application examples in tissue engineering.

Main Results:

  • dECM-based injectable hydrogels exhibit excellent biocompatibility and malleability.
  • These hydrogels facilitate cell infiltration and tissue regeneration.
  • Various preparation methods yield hydrogels with diverse properties suitable for different applications.

Conclusions:

  • dECM-based injectable hydrogels are promising for tissue engineering and regenerative medicine.
  • Further research into their prospects and challenges is essential for clinical translation.
  • These composites offer versatile solutions for complex tissue defects and organ repair.