Related Experiment Video
Updated: Jun 11, 2025
07:39
Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
37
Acute promyelocytic leukemia: A rare presentation without systemic disease
Nurfiza Ladak1, Ying Liu1, Amanda Burke1
1Department of Pathology, Hematopathology Service, Memorial Sloan Kettering Cancer Center, United States.
Human Pathology Reports
|October 1, 2024
Summary
This case study highlights a rare instance of acute promyelocytic leukemia (APL) localized solely to bone lesions. Early all-trans-retinoic acid (ATRA) treatment is crucial for APL, but this case presented without systemic involvement.
Area of Science:
- Hematology
- Oncology
- Bone Diseases
Background:
- Acute promyelocytic leukemia (APL) is a high-risk subtype of acute myeloid leukemia.
- APL typically presents with coagulopathy, including disseminated intravascular coagulation.
- Prompt treatment with all-trans-retinoic acid (ATRA) is vital to prevent bleeding and thrombosis.
Purpose of the Study:
- To report a unique case of APL.
- To describe an unusual presentation of APL isolated to bone lesions.
- To discuss the implications for diagnosis and treatment.
Main Methods:
- Case report review.
- Clinical data analysis.
- Diagnostic imaging and biopsy interpretation.
Main Results:
- A patient presented with APL exclusively involving femoral bone lesions.
- No peripheral blood or bone marrow involvement was detected.
- The patient had no systemic coagulopathy or other sequelae.
Conclusions:
- APL can present with focal bone lesions without systemic disease.
- This presentation challenges typical diagnostic criteria for APL.
- Further investigation into localized APL presentations is warranted.
More Related Videos
Related Concept Videos
01:27Disorders of Leukocytes
902
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
902
01:22Bone Marrow Sampling and Transplants
313
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
313
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K