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Updated: Jun 11, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

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Gender-specific correlations between remnant cholesterol and severe abdominal aortic calcification in American adults

Laisha Yan1, Xiaoyan Hu1, Shanshan Wu1

  • 1Department of Cardiosurgery Intensive Care Unit, Ningbo Medical Centre Li Huili Hospital, Ningbo, China.

Frontiers in Endocrinology
|October 1, 2024
PubMed

Insights

Higher remnant cholesterol (RC) levels significantly increase the risk of severe abdominal aortic calcification (AAC) in women. This association was not observed in men, indicating a gender-specific link between RC and AAC prevalence.

Area of Science:

  • Cardiovascular research
  • Metabolic health
  • Epidemiology

Background:

  • Remnant cholesterol (RC) is a known predictor of cardiovascular disease risk.
  • RC is linked to various health conditions, including hypertension and liver disease.
  • The relationship between RC and abdominal aortic calcification (AAC) remains unexplored.

Purpose of the Study:

  • To investigate the correlation between remnant cholesterol (RC) and the prevalence of severe abdominal aortic calcification (AAC).
  • To examine potential gender differences in the association between RC and severe AAC.

Main Methods:

  • Cross-sectional analysis of data from the 2013-2014 National Health and Nutrition Examination Survey (NHANES).
  • Utilized multiple logistic regression and generalized summation models.
  • Performed subgroup analyses and threshold effect analysis to assess the RC-AAC relationship.

Main Results:

  • A significant positive correlation was found between RC and severe AAC in female participants.
  • No significant correlation was observed between RC and severe AAC in male participants.
  • A significant interaction between gender and RC in relation to severe AAC was identified (P=0.0042).

Conclusions:

  • Elevated remnant cholesterol (RC) levels are significantly associated with increased prevalence of severe abdominal aortic calcification (AAC) in women.
  • The findings highlight a gender-specific relationship between RC and AAC.
  • Further research may elucidate the mechanisms underlying this observed gender difference.
Abstract

Keywords:
NHANESabdominal aortic calcificationcholesterolgender differencesremnant cholesterol

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