Expression and Clinical Significance of Nuclear Phosphoglucomutase-1 in Hepatocellular Carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Low nuclear phosphoglucomutase-1 (PGM1) expression predicts poor prognosis in hepatocellular carcinoma (HCC) patients. Nuclear PGM1 serves as a valuable prognostic biomarker, improving predictions when combined with other clinical factors.
Area Of Science
- Oncology
- Biomarker Discovery
Background
- Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide.
- Accurate prognostic biomarkers are crucial for effective patient management and treatment strategies in HCC.
Purpose Of The Study
- To investigate the prognostic value of phosphoglucomutase-1 (PGM1) expression in patients with HCC.
- To assess the potential of nuclear PGM1 as an independent prognostic biomarker for HCC.
Main Methods
- Immunohistochemistry was used to assess PGM1 expression in HCC tissue microarrays.
- Statistical analyses, including Chi-squared test and Cox regression, were employed to evaluate prognostic significance.
- Receiver operating characteristic (ROC) curve analysis determined the accuracy of predictors.
- Patient-derived xenograft models were utilized to explore the antitumor effects of nuclear PGM1.
Main Results
- PGM1 expression was found to be significantly lower in HCC tissues compared to normal tissues.
- Low nuclear PGM1 expression was independently associated with poorer overall survival and shorter time to recurrence in HCC patients.
- Nuclear PGM1, serum α-fetoprotein, liver cirrhosis, and TNM staging were identified as independent risk predictors for HCC.
- Combining nuclear PGM1 with other independent predictors demonstrated superior prognostic accuracy compared to TNM staging alone.
- HCC patient-derived xenograft models indicated an antitumor effect of nuclear PGM1.
Conclusions
- Low nuclear PGM1 expression is a significant indicator of poor prognosis in HCC.
- Nuclear PGM1 is a valuable and independent prognostic biomarker for HCC.
- The combination of nuclear PGM1 with other clinical factors enhances prognostic prediction in HCC patients.
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