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Diffuse idiopathic skeletal hyperostosis is associated with greater complexity of coronary artery disease burden on

G Adami1, S Zanon2, A Fassio1

  • 1Rheumatology Unit, University of Verona.

Reumatismo
|October 1, 2024
PubMed

Insights

Diffuse idiopathic skeletal hyperostosis (DISH) is linked to more complex coronary artery disease (CAD). This study found DISH independently associated with higher CAD complexity, particularly in younger patients, suggesting a potential role in cardiovascular risk assessment.

Area of Science:

  • Cardiology
  • Radiology
  • Rheumatology

Background:

  • Diffuse idiopathic skeletal hyperostosis (DISH) involves ossification of tendons and ligaments.
  • DISH is frequently associated with metabolic syndrome and type 2 diabetes.
  • The relationship between DISH and coronary artery disease (CAD) risk requires further investigation.

Purpose of the Study:

  • To explore the association between DISH and the risk of coronary artery disease (CAD).
  • To determine if DISH is an independent predictor of CAD complexity.

Main Methods:

  • An observational cross-sectional study included 187 patients undergoing coronary angiography.
  • DISH diagnosis was confirmed using standard X-ray and CT scans (Resnick criteria).
  • The SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery (SYNTAX) score was used to assess CAD complexity, analyzed via logistic regression models.

Main Results:

  • 44.4% of patients had a confirmed DISH diagnosis.
  • DISH was significantly associated with a higher SYNTAX score (aOR 34.1, p=0.049), independent of cardiovascular risk factors.
  • In patients under 70, DISH correlated with a 7-fold increased risk of highest SYNTAX score (≥34) (aOR 7.23, p=0.041).
  • Vertebral calcification extent correlated with SYNTAX score (r² 0.378, p<0.0001).

Conclusions:

  • DISH is prevalent in patients with high cardiovascular risk or established CAD.
  • DISH is independently associated with increased complexity of coronary artery disease.
Abstract

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