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Specific amino acid changes correlate with pathogenic flavobacteria.

Vincent Gélinas1,2, Valérie E Paquet1,2,3, Maude F Paquet1,2

  • 1Institut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Quebec City, QC G1V 0A6, Canada.

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|October 1, 2024
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Summary
This summary is machine-generated.

Specific amino acid changes in Flavobacterium bacteria may explain their adaptation to fish. These changes in the CII clade are linked to replication and repair functions, potentially driving fish pathogenicity.

Keywords:
Flavobacteriumadaptationcore protein changesfish pathogensgenetic enrichmentsphylogeny

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Area of Science:

  • Microbiology
  • Genomics
  • Evolutionary Biology

Background:

  • The genus *Flavobacterium* comprises diverse microorganisms found globally in various environments.
  • Certain *Flavobacterium* species, like *F. psychrophilum* and *F. columnare*, cause significant diseases and economic losses in aquaculture.
  • The evolutionary pathways leading to fish pathogenicity in *Flavobacterium* and the specific protein alterations driving fish colonization remain largely unknown.

Purpose of the Study:

  • To investigate the evolutionary origins of fish-pathogenic *Flavobacterium* species.
  • To identify specific protein changes associated with the adaptation and colonization of fish by *Flavobacterium*.

Main Methods:

  • Phylogenetic analysis of 208 *Flavobacterium* species using 861 softcore genes.
  • Identification of conserved amino acid changes within specific clades.

Main Results:

  • Phylogenetic analysis identified a clade (CII) containing nine species, including five fish pathogens and the majority of fish-colonizing species.
  • Thirteen specific amino acid changes were conserved across 11 proteins within the CII clade.
  • These proteins are predominantly involved in replication, recombination, and repair, with some known roles in bacterial pathogenicity and adaptation.
  • Observed amino acid changes may be influenced by codon usage bias and tRNA availability.

Conclusions:

  • The identified amino acid changes within the CII clade of *Flavobacterium* are potential drivers of adaptation to fish environments.
  • These findings provide insights into the molecular mechanisms underlying the evolution of fish pathogenicity in this genus.