Brain angiotensin II and III binding and dipsogenicity in the rabbit

The rabbit brain evidenced low or non-detectable levels of [125I]angiotensin II binding but considerable [125I]angiotensin III specific binding in agreement with distributions reported for the primate brain. The rabbit was dispsogenically responsive to the intracerebroventricular infusions of angiotensin II and III; however, no elevations in blood pressure were measured for either peptide. Thus, members of this species appear to have limited usefulness as a primate model for central angiotensin-induced cardiovascular changes.