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Bioorthogonal chemistry-based prodrug strategies for enhanced biosafety in tumor treatments: current progress and

Yongchao Yao1,2, Ying Chen3, Chang Zhou1

  • 1Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. anderson-qian@163.com.

Journal of Materials Chemistry. B
|October 1, 2024
PubMed

Insights

Developing safer cancer treatments is key. This review explores prodrugs and bioorthogonal reactions for targeted chemotherapy, aiming to reduce side effects and improve tumor treatment efficacy.

Area of Science:

  • Oncology
  • Medicinal Chemistry
  • Biochemistry

Background:

  • Chemotherapy is vital for cancer treatment but causes systemic toxicity and side effects due to non-specific drug distribution.
  • Prodrug strategies offer improved tumor targeting by activating drugs at the cancer site, but challenges remain in differentiating tumor and normal tissue microenvironments.
  • Bioorthogonal reactions provide high selectivity and precision, minimizing interference with biological processes, making them promising for advanced drug delivery.

Purpose of the Study:

  • To review the safety and efficacy of prodrug strategies that incorporate bioorthogonal reactions for cancer therapy.
  • To highlight the potential of combining prodrug activation with bioorthogonal chemistry for enhanced cancer treatment.
  • To assess the advantages of bioorthogonal chemistry in overcoming limitations of traditional prodrug approaches.

Main Methods:

  • Literature review of studies employing bioorthogonal reactions in prodrug design for cancer treatment.
  • Analysis of safety profiles and efficacy data from preclinical and clinical investigations.
  • Evaluation of the specificity and targeting capabilities of bioorthogonal prodrug systems.

Main Results:

  • Bioorthogonal prodrug strategies demonstrate high selectivity, activating drugs specifically within the tumor microenvironment.
  • These approaches significantly reduce systemic toxicity compared to conventional chemotherapy.
  • Enhanced therapeutic efficacy has been observed in various cancer models utilizing bioorthogonal activation mechanisms.

Conclusions:

  • Prodrug strategies combined with bioorthogonal reactions represent a promising advancement in developing safer and more effective cancer chemotherapy.
  • The precision of bioorthogonal reactions offers a robust solution to the challenge of off-target drug activation.
  • Further research and clinical translation of these innovative strategies hold significant potential for improving patient outcomes in oncology.

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