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Updated: Jun 11, 2025

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Exploring the dichotomy of the mesenchymal stem cell secretome: Implications for tumor modulation via cell-signaling

Mohammad Rasouli1, Mana Alavi1, Alberto D'Angelo2

  • 1Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran.

International Immunopharmacology
|October 1, 2024
PubMed

Insights

Mesenchymal stem cells (MSCs) offer a novel anticancer platform due to their unique properties. Their secretome can either promote or inhibit tumor growth, acting as a double-edged sword in cancer therapy.

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Biotechnology

Background:

  • Current cancer therapies face challenges with side effects and drug resistance.
  • Stem cell-based treatments are emerging as promising anticancer platforms.
  • Mesenchymal stem cells (MSCs) possess unique biological properties, including self-renewal and low immunogenicity.

Purpose of the Study:

  • To review the role of mesenchymal stem cell (MSC) secretome in cancer.
  • To explore the dual role of MSC secretome in tumor regulation.
  • To highlight MSCs as a potential anticancer therapeutic strategy.

Main Methods:

  • Review of current literature on MSC secretome and cancer.
  • Analysis of bioactive factors secreted by MSCs.
  • Examination of signaling pathways influenced by MSC secretome.

Main Results:

  • MSC secretome contains trophic factors like cytokines, chemokines, and microRNAs.
  • These factors can exhibit context-dependent effects on tumor growth.
  • MSCs can act as a double-edged sword, either suppressing or promoting tumors.

Conclusions:

  • The MSC secretome presents a complex but potent therapeutic avenue for cancer treatment.
  • Understanding the tumor microenvironment is crucial for harnessing MSCs' anticancer potential.
  • Further research into MSC secretome modulation is warranted for effective cancer therapy.
Keywords:
Cell signal transduction pathwaysSecretome of MSCsTumor promotionTumor suppression

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