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Updated: Jun 11, 2025

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
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GSDMB interacts with IGF2BP1 to suppress colorectal cancer progression by modulating DUSP6-ERK pathway

Haiyang Jiang1, Liting Deng2, Zexing Lin3

  • 1Department of General Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China; BenQ Medical Center, the Affiliated BenQ Hospital of Nanjing Medical University, Nanjing 210019, China.

International Immunopharmacology
|October 1, 2024
PubMed

Insights

Gasdermin B (GSDMB) suppresses colorectal cancer (CRC) progression. Upregulated GSDMB inhibits tumor growth by enhancing DUSP6 translation, offering a potential new therapeutic target for CRC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gastroenterology

Background:

  • Gasdermin family proteins are implicated in cancer progression.
  • The specific role of Gasdermin B (GSDMB) in colorectal cancer (CRC) tumorigenesis remains unclear.
  • GSDMB is notably abundant in gastrointestinal tract epithelial cells.

Purpose of the Study:

  • To elucidate the role of GSDMB in regulating colorectal cancer progression.
  • To investigate the molecular mechanisms by which GSDMB influences CRC tumorigenesis.

Main Methods:

  • In vitro cell culture and intestinal organoid models were utilized.
  • In vivo studies employed GSDMB transgenic mouse models.
  • Mechanistic studies involved investigating protein-protein interactions and mRNA binding.

Main Results:

  • Aberrantly upregulated GSDMB was found to suppress CRC progression.
  • GSDMB interacts with IGF2BP1, which binds to DUSP6 mRNA.
  • This interaction enhances DUSP6 translation, inhibiting ERK phosphorylation and promoting cell death while restraining proliferation.

Conclusions:

  • GSDMB acts as a suppressor of colorectal cancer progression.
  • The GSDMB-IGF2BP1-DUSP6 pathway is a key mechanism in GSDMB's tumor-suppressive function.
  • GSDMB presents a promising novel therapeutic target for colorectal cancer treatment.
Keywords:
Cell deathCell proliferationColorectal cancerGSDMBIGF2BP1

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