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AVM: A Manually Curated Database of Aerosol-transmitted Virus Mutations, Human Diseases, and Drugs

Lan Mei1, Yaopan Hou1, Jiajun Zhou1

  • 1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.

Genomics, Proteomics & Bioinformatics
|October 1, 2024
PubMed

Insights

A new database, AVM, tracks aerosol-transmitted virus mutations and their impact on diseases and treatments. This resource aids in understanding and combating these highly infectious agents.

Area of Science:

  • Virology
  • Bioinformatics
  • Genomics

Background:

  • Aerosol-transmitted viruses are highly infectious and pose significant public health threats.
  • Viral mutations can enhance transmissibility, virulence, and immune evasion, impacting vaccine and drug efficacy.
  • Existing resources lack comprehensive, integrated data on aerosol-transmitted viral mutations.

Purpose of the Study:

  • To establish a manually curated database (AVM) for aerosol-transmitted viral mutations (VMs).
  • To consolidate information on viral mutations, associated diseases, and therapeutic interventions.
  • To provide a user-friendly platform for accessing and utilizing this data.

Main Methods:

  • Manual curation of viral mutation data.
  • Integration of clinical information, drug, antibody, and vaccine data.
  • Development of a searchable and downloadable database interface.

Main Results:

  • The AVM database currently contains 42,041 VMs, including 2613 immune escape mutations.
  • It includes 45 clinical information datasets and data on 407 drugs, antibodies, and vaccines.
  • 88 human diseases linked to viruses were recorded, highlighting diverse organ targeting.

Conclusions:

  • The AVM database serves as a comprehensive resource for aerosol-transmitted viruses.
  • It facilitates timely access to critical information on viral transmission, mutation, and treatment.
  • This resource supports research and public health efforts against these infectious agents.
Keywords:
AerosolDrugHuman diseaseImmune escape mutationViral mutation

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