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Trends in bacterial susceptibility to antimicrobial agents
Chemotherapy
|January 1, 1985
Summary
Antimicrobial resistance trends show decreasing susceptibility in common pathogens like Staphylococcus aureus and Pseudomonas aeruginosa. However, some gram-negative bacteria are becoming more susceptible to certain drugs.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Antimicrobial Stewardship
Background:
- Growing concern regarding the increasing prevalence of antimicrobial resistance in common bacterial pathogens.
- Need to identify institutional trends in drug resistance to inform treatment strategies.
Purpose of the Study:
- To analyze antimicrobial susceptibility trends over an eight-year period (1975-1982) at the Veterans Administration Medical Center in Oklahoma City.
- To identify specific pathogens exhibiting increasing or decreasing susceptibility to antimicrobial agents.
Main Methods:
- Review of susceptibility data for 18 organisms and 21 antimicrobial agents.
- Analysis of 64 major drug-organism combinations.
- Retrospective study design.
Main Results:
- Decreasing susceptibility observed in gram-positive organisms (enterococcus group D, Staphylococcus aureus) and Pseudomonas aeruginosa.
- Increasing susceptibility noted in gram-negative bacilli including Proteus, Serratia, Enterobacter spp., and Klebsiella pneumoniae to certain drugs.
Conclusions:
- Specific pathogens demonstrate evolving resistance patterns, necessitating ongoing monitoring.
- Identified trends in antimicrobial susceptibility can guide empirical therapy and antimicrobial stewardship efforts.