Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

Search research articles

Home
Outcomes And Failure Patterns After Chemoradiotherapy For Locally Advanced Rectal Cancer With Positive Lateral Pelvic Lymph Nodes: A Propensity Score-matched Analysis.

Home
Outcomes And Failure Patterns After Chemoradiotherapy For Locally Advanced Rectal Cancer With Positive Lateral Pelvic Lymph Nodes: A Propensity Score-matched Analysis.

Related Experiment Video

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Outcomes and failure patterns after chemoradiotherapy for locally advanced rectal cancer with positive lateral pelvic

Shuai Li¹, Maxiaowei Song¹, Jian Tie¹

¹Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, 100142, China.

Radiation Oncology (London, England)

|October 1, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Keywords:

Lateral pelvic lymph nodes Locally advanced rectal cancer Oligometastases Progression-free survival Propensity score matching Recurrence patterns

More Related Videos

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

Related Experiment Videos

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

Locally advanced rectal cancer patients with positive lateral pelvic lymph nodes show a trend toward worse progression-free survival and distant metastasis. Further research with larger cohorts is needed to confirm these findings for lateral pelvic lymph node-positive patients.

Area of Science:

Oncology
Surgical Oncology
Rectal Cancer Research

Background:

Lateral pelvic lymph node (LPLN) involvement is a critical prognostic factor in locally advanced rectal cancer (LARC).
Understanding the long-term outcomes associated with LPLN status is crucial for treatment planning and patient management.

Purpose of the Study:

To investigate the long-term outcomes and failure patterns in LARC patients based on the presence or absence of lateral pelvic lymph node metastasis.
To utilize propensity score matching (PSM) to control for confounding factors and provide a robust comparison between LPLN-positive and LPLN-negative groups.

Main Methods:

Retrospective analysis of 651 LARC patients, divided into LPLN-positive and LPLN-negative groups.
Propensity score matching (PSM) was employed to balance baseline clinical characteristics between the two groups.

Kaplan-Meier analysis and log-rank tests were used to compare progression-free survival (PFS), overall survival (OS), local-regional recurrence (LRR), and distant metastasis (DM) rates.

Main Results:

After PSM, 114 patients were analyzed in each group, with balanced clinical factors.
No significant differences were observed in 3-year OS (88.3% vs. 92.1%) and LRR (5.7% vs. 2.8%) between LPLN-positive and LPLN-negative patients.
A trend towards worse 3-year PFS (78.8% vs. 85.9%) and higher DM rates (20.4% vs. 13.3%) was noted in the LPLN-positive group, although not statistically significant (P=0.065 and P=0.061, respectively).

Conclusions:

LPLN-positive status in LARC patients may be associated with a tendency for worse progression-free survival and increased distant metastasis.
Larger sample sizes are required to definitively confirm these observed trends and their clinical significance.
The study highlights the importance of considering LPLN status in the prognostic evaluation of LARC.