Related Experiment Video

Updated: Jun 11, 2025

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification
07:50

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

Published on: June 2, 2020

5.2K

Progression of mesenchymal stem cell regulation on imbalanced microenvironment after spinal cord injury

Yifan Liu1,2, Chenxi Zhao1, Rong Zhang1

  • 1Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, 107 West Wenhua Road, Lixia District, Jinan, 250012, Shandong, China.

Stem Cell Research & Therapy
|October 1, 2024
PubMed

Insights

Mesenchymal stem cell (MSC) transplantation shows promise for spinal cord injury (SCI) by regulating the microenvironment. This review explores MSCs

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Spinal cord injury (SCI) causes neural damage and inhibits axon regeneration due to a detrimental microenvironment.
  • The imbalanced microenvironment post-SCI is characterized by inflammation and lack of neurotrophic support.
  • Mesenchymal stem cells (MSCs) are being investigated for their therapeutic potential in SCI.

Purpose of the Study:

  • To review the role of Mesenchymal Stem Cell (MSC) transplantation in modulating the SCI microenvironment.
  • To focus on MSC regulation of inflammation, neurotrophy, and axonal regeneration.
  • To provide a comprehensive perspective on MSC application for SCI clinical translation.

Main Methods:

  • Literature review of studies on MSC transplantation for SCI.
  • Analysis of MSC effects on inflammatory responses in the SCI microenvironment.
  • Evaluation of MSC-mediated neurotrophic support and axonal regeneration promotion.

Main Results:

  • MSCs can modulate the inflammatory milieu following SCI.
  • MSC transplantation can enhance neurotrophic factor availability.
  • Evidence suggests MSCs promote axonal regeneration in SCI models.

Conclusions:

  • MSC transplantation is a promising therapeutic strategy for SCI.
  • Further research is needed to optimize MSC application and overcome limitations for clinical translation.
  • MSC therapy holds potential for improving functional recovery after spinal cord injury.
Keywords:
Mesenchymal stem cellsMicroenvironment imbalanceParacrineSpinal cord injury

More Related Videos

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury10:56

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

13.0K
Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury09:56

Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury

Published on: July 27, 2014

12.4K

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.6K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
739
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.0K