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Updated: Jun 11, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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Assessing the limitations of relief-based algorithms in detecting higher-order interactions

Philip J Freda1, Suyu Ye2, Robert Zhang3

  • 1Computational Biomedicine, Cedars-Sinai Medical Center, 700 N. San Vicente Blvd., Pacific Design Center, Suite G540, West Hollywood, 90069, CA, USA.

Biodata Mining
|October 1, 2024
PubMed
Summary

Relief-Based Algorithms (RBAs) struggle with detecting complex, higher-order epistasis, especially in large datasets. Absolute value ranking shows promise for specific 4-way interactions but requires further development for broader application.

Keywords:
EpistasisFeature selectionHeterogeneityHigh-orderInteractionsRBARelief-based algorithmReliefFUnivariate

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