Feasibility of Monitoring Tissue Properties During Microcirculation Disorder Using a Compact Fiber-Based Probe With...

Area of Science:

• Biomedical Engineering
• Optical Diagnostics
• Surgical Monitoring

Background:

• Microcirculation disorders during surgery can lead to tissue hypoxia, ischemia, and necrosis.
• Early detection of these disorders is crucial for preventing adverse surgical outcomes.
• Current methods for intraoperative monitoring of microcirculation are limited.

Purpose of the Study:

• To develop and validate a compact optical probe for intraoperative detection of microcirculation disorders.
• To assess the probe's ability to measure tissue optical properties and detect changes indicative of stress.
• To evaluate the probe's feasibility for surgical operations and diagnostic purposes.

Main Methods:

• A compact probe with a sapphire tip utilizing spatially resolved diffuse reflectance analysis was designed.
• The probe measures the tissue effective attenuation coefficient and its alterations.
• Experimental studies were conducted using a tissue-mimicking phantom and a rat hindlimb ischemia model.

Main Results:

• The probe successfully measured the effective attenuation coefficient in tissue phantoms and animal models.
• Rapid changes in tissue attenuation were detected, confirming the probe's sensitivity to stressful conditions.
• The compact design facilitates its use in various surgical procedures.

Conclusions:

• The developed optical probe is feasible for intraoperative detection of microcirculation disorders.
• The probe can sense rapid tissue changes caused by microcirculation alterations.
• Its compact design makes it a potentially valuable auxiliary instrument for surgery and diagnostics.