Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

86
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
86
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

91
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
91
Positron Emission Tomography01:29

Positron Emission Tomography

4.0K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Terbium-161 might be superior to lutetium-177 for oligometastases - Authors' reply.

The Lancet. Oncology·2026
Same author

Economic burden of breast cancer in Cyprus from a societal perspective.

Expert review of pharmacoeconomics & outcomes research·2026
Same author

Evaluation of PET/CT Artificial Intelligence Image Reconstructions VS Harmonized Clinical Reconstruction.

Zeitschrift fur medizinische Physik·2026
Same author

PSA persistence in the PSMA PET era: reassessing a risk factor after radical prostatectomy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

[<sup>177</sup>Lu]-PSMA-617-PSMA-617 in oligometastatic hormone sensitive prostate cancer (BULLSEYE): an open-label, randomised, phase 2 study.

The Lancet. Oncology·2026
Same author

Survival outcomes and toxicity profile after CT-guided HDR brachytherapy (interventional radiotherapy) for liver oligometastases in breast cancer patients: The BRALIBREST real world multicenter study.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2025

Related Experiment Video

Updated: Jun 11, 2025

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

9.9K

Case Report: Post-traumatic splenosis and potential pitfall for PSMA-PET.

Marina Nearchou1, Elizabeth Georgiou1, Alexis Vrachimis2

  • 1Department of Radiation Oncology, German Oncology Centre, University Hospital of the European University, Limassol, Cyprus.

Frontiers in Nuclear Medicine
|October 2, 2024
PubMed
Summary

18F-PSMA PET/CT identified intraabdominal formations in a prostate cancer patient. These were correctly diagnosed as splenosis, not peritoneal spread, using 99mTc-sulphur colloid SPECT, showcasing nuclear medicine's diagnostic power.

Keywords:
18F-PSMA PET/CT99mTc-sulphur colloid SPECTectopic splenic tissuefalse positiveprostate cancersplenosis

More Related Videos

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

6.8K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

315

Related Experiment Videos

Last Updated: Jun 11, 2025

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

9.9K
Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

6.8K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

315

Area of Science:

  • Nuclear Medicine
  • Oncology
  • Radiology

Background:

  • 18F-prostate specific membrane antigen (PSMA) PET/CT is a leading imaging modality for prostate cancer staging and re-staging.
  • Potential pitfalls in 18F-PSMA PET interpretation can lead to misdiagnosis.
  • This case highlights a rare diagnostic challenge in prostate cancer imaging.

Observation:

  • A 67-year-old male with high-risk prostate cancer presented with unexpected intraabdominal findings on 18F-PSMA-1007 PET/CT.
  • The patient had a history of childhood splenic rupture, raising suspicion for post-traumatic splenosis.
  • Multiple highly PSMA-avid intraabdominal lesions were noted, mimicking metastatic disease.

Findings:

  • 18F-PSMA-1007 PET/CT revealed multiple intraabdominal lesions with high PSMA expression.
  • 99mTc-sulphur colloid SPECT confirmed the presence of functional ectopic splenic tissue (splenosis).
  • The findings underscore the importance of integrating clinical history with imaging findings.

Implications:

  • This case demonstrates a potential false positive for peritoneal spread in 18F-PSMA PET/CT due to splenosis.
  • Nuclear medicine techniques, including SPECT, are crucial for accurate diagnosis in complex cases.
  • Accurate interpretation of PSMA PET/CT requires awareness of potential mimics like splenosis.