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Related Experiment Video

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Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
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Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

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Theranostics in breast cancer.

M Vorster1, B P Hadebe1, M M Sathekge2

  • 1Department of Nuclear Medicine, University of KwaZulu-Natal, Durban, South Africa.

Frontiers in Nuclear Medicine
|October 2, 2024
PubMed
Summary
This summary is machine-generated.

Theranostic approaches show promise for improving breast cancer diagnosis and treatment. Further research is needed to overcome challenges and optimize these targeted therapies for better patient outcomes.

Keywords:
CXCR4FAPIRLT/radioligand therapybreast cancertargeted radionuclide therapytheranostics

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiopharmaceutical Therapy

Background:

  • Breast cancer is a leading global cancer in women, with conventional treatments having limitations and significant side effects.
  • Targeted radionuclide therapy, utilizing a theranostic approach, has shown success in other cancers and holds potential for breast cancer.
  • Theranostics combines diagnostic imaging and targeted therapy for personalized cancer treatment.

Purpose of the Study:

  • To review promising current and future theranostic approaches for breast cancer.
  • To highlight key molecular targets and their potential in breast cancer theranostics.
  • To discuss challenges hindering the clinical implementation of theranostic strategies in breast cancer.

Main Methods:

  • Review of pre-clinical and clinical data on theranostic applications in breast cancer.
  • Analysis of various molecular targets, including HER2, angiogenesis markers, and receptors like GRPR, PSMA, and CXCR-4.
  • Examination of challenges related to regulatory approval, radiopharmaceutical access, imaging technology, cost-effectiveness, and clinical data.

Main Results:

  • Several theranostic targets show potential for breast cancer, including HER2, angiogenesis, tumor microenvironment, GRPR, PSMA, and CXCR-4.
  • Pre-clinical and clinical data support the feasibility of these targeted approaches.
  • Significant challenges remain for widespread clinical adoption, including regulatory and logistical hurdles.

Conclusions:

  • Theranostic approaches offer significant potential to enhance breast cancer diagnosis, treatment efficacy, and patient outcomes.
  • Further research is crucial to identify optimal targets and refine theranostic strategies.
  • Addressing feasibility, cost, efficacy, and side effect profiles is essential for successful implementation.