Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

4.0K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.0K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

91
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
91

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Long vs. short axial field-of-view PET scanners for brain imaging: a phantom study.

Frontiers in nuclear medicine·2026
Same author

Total Body PET.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same author

Validation of a Deep-Learning Coregistration Framework for Long-Axial-Field-of-View PET/CT Using Low-Radiation-Exposure Protocols Across Various Tracers.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Developing Topics.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Delayed [<sup>89</sup>Zr]Zr-<i>N</i>-Succinyldesferal-Trastuzumab Imaging Enabled by Long-Axial-Field-of-View PET/CT.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025
Same author

Influence of Ultra-Low-Dose CT on PET Image Quantification and Visual Assessment.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025
Same journal

Driving clinical excellence through a management driven framework for integrating nuclear medicine into hospital ecosystems.

Frontiers in nuclear medicine·2026
Same journal

Availability, accessibility, and economic feasibility of radionuclide therapies in Africa: a systematic review and quantitative infrastructure analysis.

Frontiers in nuclear medicine·2026
Same journal

Impact of reader experience on the time-saving potential of a novel computer-aided tool for Ann Arbor staging of pediatric hodgkin lymphoma.

Frontiers in nuclear medicine·2026
Same journal

Physiological biodistribution of <sup>18</sup>F-fluciclovine PET in the head: as a baseline for interpretation in patients with suspected glioma.

Frontiers in nuclear medicine·2026
Same journal

Radiopharmacy services in South African academic hospitals: implications for planning radiopharmacy services in Africa.

Frontiers in nuclear medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 11, 2025

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
10:47

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

8.7K

Advances and challenges in immunoPET methodology.

Philipp Mohr1, Joyce van Sluis1, Marjolijn N Lub-de Hooge1,2

  • 1Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Frontiers in Nuclear Medicine
|October 2, 2024
PubMed
Summary
This summary is machine-generated.

Immuno-positron emission tomography (immunoPET) uses radiolabeled antibodies to visualize disease targets, guiding drug development and patient selection for therapies. This review covers semi-quantitative and pharmacokinetic modeling methods for immunoPET imaging.

Keywords:
PET/CTimagingimmunoPETkinetic modelingmonoclonal antibodyquantificationzirconium

More Related Videos

Determining Binding Affinity KD of Radiolabeled Antibodies to Immobilized Antigens
07:39

Determining Binding Affinity KD of Radiolabeled Antibodies to Immobilized Antigens

Published on: June 23, 2022

6.1K
Author Spotlight: Standardizing Mouse In Vivo PET Imaging with Body Conforming Molds and Automated Analysis
07:45

Author Spotlight: Standardizing Mouse In Vivo PET Imaging with Body Conforming Molds and Automated Analysis

Published on: October 25, 2024

331

Related Experiment Videos

Last Updated: Jun 11, 2025

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
10:47

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

8.7K
Determining Binding Affinity KD of Radiolabeled Antibodies to Immobilized Antigens
07:39

Determining Binding Affinity KD of Radiolabeled Antibodies to Immobilized Antigens

Published on: June 23, 2022

6.1K
Author Spotlight: Standardizing Mouse In Vivo PET Imaging with Body Conforming Molds and Automated Analysis
07:45

Author Spotlight: Standardizing Mouse In Vivo PET Imaging with Body Conforming Molds and Automated Analysis

Published on: October 25, 2024

331

Area of Science:

  • Nuclear medicine
  • Molecular imaging
  • Radiopharmaceutical science

Background:

  • Immuno-positron emission tomography (immunoPET) visualizes specific targets for targeted therapy and immunotherapy.
  • Commonly uses monoclonal antibodies labeled with positron emitters like 89Zr.
  • Smaller antibody-based constructs are also under investigation.

Purpose of the Study:

  • To review imaging methodologies in immunoPET studies.
  • To summarize semi-quantitative and pharmacokinetic modeling approaches.
  • To discuss quantification potential and challenges, considering new PET/CT technology.

Main Methods:

  • Review of clinical immunoPET studies using semi-quantitative methodologies.
  • Focus on studies employing pharmacokinetic models (preclinical and simulation).
  • Discussion of quantification methodologies in the context of long axial field of view PET/CT scanners.

Main Results:

  • The majority of clinical immunoPET studies utilize semi-quantitative methods.
  • Pharmacokinetic modeling studies are fewer but provide deeper insights.
  • Advancements in PET/CT technology are enhancing quantification potential.

Conclusions:

  • ImmunoPET is a valuable tool for guiding drug development and patient selection.
  • Semi-quantitative methods are widely used, but pharmacokinetic modeling offers more detailed analysis.
  • Further development of quantification methodologies is crucial for maximizing immunoPET's clinical impact.