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Updated: Jun 11, 2025
10:38
Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
Published on: January 16, 2019
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Point-of-care creatinine vs. central laboratory creatinine in the critically ill
Kyle C White1,2,3, James McCullough4,5, Kiran Shekar2,3,6
1Intensive Care Unit, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
Summary
Point-of-care testing (POCT) for creatinine measurement is equivalent to central laboratory testing in critically ill patients. This allows for more frequent kidney function monitoring and earlier acute kidney injury detection.
Area of Science:
- Clinical Chemistry
- Critical Care Medicine
- Nephrology
Background:
- Frequent creatinine monitoring aids early acute kidney injury (AKI) detection in critically ill patients.
- Equivalence of point-of-care testing (POCT) to central laboratory creatinine measurement requires robust data.
Purpose of the Study:
- Compare POCT creatinine measurement with central laboratory creatinine measurement.
- Assess the clinical equivalence of POCT for creatinine in critically ill patients.
Main Methods:
- Multicenter retrospective observational study.
- Paired creatinine measurements (POCT vs. central lab) from 19,118 critically ill patients.
- Analysis of mean difference, bias, and limits of agreement.
Main Results:
- 79,767 paired measurements were analyzed.
- POCT creatinine values closely correlated with central lab values (Pearson coefficient 0.99).
- Mean difference was minimal (0.49 μmol/L) with wide but clinically acceptable limits of agreement (-27 to +28 μmol/L).
Conclusions:
- POCT creatinine measurement is clinically equivalent to central laboratory testing in critically ill patients.
- POCT facilitates frequent kidney function monitoring.
- Supports earlier detection of AKI using POCT.
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