Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 11, 2025

Zebra II as A Novel System to Record Electrophysiological Signals in Zebrafish
06:15

Zebra II as A Novel System to Record Electrophysiological Signals in Zebrafish

Published on: August 16, 2024

395

Zebrafish as a Model System for Brugada Syndrome.

Leonie Verkerk1, Arie O Verkerk1,2, Ronald Wilders1

  • 1Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

Reviews in Cardiovascular Medicine
|October 2, 2024
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AAV-mediated long-term TBX18 expression causes cardiac fibrosis and fails to induce pacemaker activity in rodents.

The Journal of clinical investigation·2026
Same author

SGK1-inhibition restores cardiac repolarization in LQT2 rabbits and LQT3 mice by reducing late sodium current.

Pharmacological research·2026
Same author

Silencing the Mutant <i>KCNH2</i> Allele to Reduce the Effects of Long QT Syndrome Type 2.

Frontiers in bioscience (Landmark edition)·2026
Same author

PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias.

Nature communications·2025
Same author

A Better Understanding of Atrial-like and Ventricular-like Action Potentials in Stem Cell-Derived Cardiomyocytes: The Underestimated Role of the L-Type Ca<sup>2+</sup> Current.

Cells·2025
Same author

Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient.

The Journal of physiology·2025

Brugada syndrome (BrS) research can benefit from zebrafish models. These fish offer valuable insights into BrS mechanisms and potential drug screening for this inheritable cardiac disease.

Area of Science:

  • Cardiology
  • Genetics
  • Translational Medicine

Background:

  • Brugada syndrome (BrS) is an inheritable cardiac arrhythmogenic disease increasing sudden cardiac death risk.
  • Current treatments like implantable cardioverter-defibrillators (ICDs) have limitations, necessitating improved diagnostics and therapies.
  • Understanding BrS pathophysiology and genetic basis is crucial for advancing patient care.

Purpose of the Study:

  • To evaluate the utility of zebrafish (Danio rerio) as an experimental model for Brugada syndrome research.
  • To review the existing literature on zebrafish use in studying BrS mechanisms.
  • To assess the potential of zebrafish for genetic studies and drug screening in BrS.

Main Methods:

  • Literature review on zebrafish as a model for cardiac arrhythmias and specifically for Brugada syndrome.
Keywords:
Brugada syndromeDanio rerioaction potentialcardiomyocyteselectrophysiologyhearthumansodium currentventriclezebrafish

More Related Videos

CRISPR-Cas9-Mediated Precise Knock-In Edits in Zebrafish Hearts
06:52

CRISPR-Cas9-Mediated Precise Knock-In Edits in Zebrafish Hearts

Published on: September 13, 2022

3.4K
In Vivo Surface Electrocardiography for Adult Zebrafish
09:13

In Vivo Surface Electrocardiography for Adult Zebrafish

Published on: August 1, 2019

14.1K

Related Experiment Videos

Last Updated: Jun 11, 2025

Zebra II as A Novel System to Record Electrophysiological Signals in Zebrafish
06:15

Zebra II as A Novel System to Record Electrophysiological Signals in Zebrafish

Published on: August 16, 2024

395
CRISPR-Cas9-Mediated Precise Knock-In Edits in Zebrafish Hearts
06:52

CRISPR-Cas9-Mediated Precise Knock-In Edits in Zebrafish Hearts

Published on: September 13, 2022

3.4K
In Vivo Surface Electrocardiography for Adult Zebrafish
09:13

In Vivo Surface Electrocardiography for Adult Zebrafish

Published on: August 1, 2019

14.1K
  • Analysis of zebrafish cardiac electrophysiology similarities to humans.
  • Discussion of zebrafish applications in gene editing and drug screening.

    • Main Results:

    • Zebrafish cardiac electrophysiology shares similarities with humans, making them suitable for arrhythmia studies.
    • Limited studies have explored zebrafish for Brugada syndrome, indicating a gap in research.
    • Zebrafish offer potential for genetic manipulation and high-throughput drug screening relevant to BrS.

    Conclusions:

    • Zebrafish represent a valuable and underutilized model for Brugada syndrome research.
    • This model can aid in elucidating BrS genetic basis and pathophysiological mechanisms.
    • Zebrafish facilitate the screening of novel therapeutic compounds for Brugada syndrome treatment.