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Zebrafish as a Model System for Brugada Syndrome
Leonie Verkerk1, Arie O Verkerk1,2, Ronald Wilders1
1Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Reviews in Cardiovascular Medicine
|October 2, 2024
Summary
Brugada syndrome (BrS) research can benefit from zebrafish models. These fish offer valuable insights into BrS mechanisms and potential drug screening for this inheritable cardiac disease.
Area of Science:
- Cardiology
- Genetics
- Translational Medicine
Background:
- Brugada syndrome (BrS) is an inheritable cardiac arrhythmogenic disease increasing sudden cardiac death risk.
- Current treatments like implantable cardioverter-defibrillators (ICDs) have limitations, necessitating improved diagnostics and therapies.
- Understanding BrS pathophysiology and genetic basis is crucial for advancing patient care.
Purpose of the Study:
- To evaluate the utility of zebrafish (Danio rerio) as an experimental model for Brugada syndrome research.
- To review the existing literature on zebrafish use in studying BrS mechanisms.
- To assess the potential of zebrafish for genetic studies and drug screening in BrS.
Main Methods:
- Literature review on zebrafish as a model for cardiac arrhythmias and specifically for Brugada syndrome.
- Analysis of zebrafish cardiac electrophysiology similarities to humans.
- Discussion of zebrafish applications in gene editing and drug screening.
Main Results:
- Zebrafish cardiac electrophysiology shares similarities with humans, making them suitable for arrhythmia studies.
- Limited studies have explored zebrafish for Brugada syndrome, indicating a gap in research.
- Zebrafish offer potential for genetic manipulation and high-throughput drug screening relevant to BrS.
Conclusions:
- Zebrafish represent a valuable and underutilized model for Brugada syndrome research.
- This model can aid in elucidating BrS genetic basis and pathophysiological mechanisms.
- Zebrafish facilitate the screening of novel therapeutic compounds for Brugada syndrome treatment.
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