Risk Factors for PVC Induced Cardiomyopathy and Post-Ablation Left Ventricular Systolic Dysfunction Reversibility: A Systematic Review and Meta-Analysis of Observational Studies
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View abstract on PubMed
Summary
This summary is machine-generated.Asymptomatic status, interpolation, and epicardial origin are key risk factors for premature ventricular complex (PVC) induced cardiomyopathy. Sinus QRS duration and PVC burden influence left ventricular systolic dysfunction reversibility after ablation.
Area Of Science
- Cardiology
- Electrophysiology
- Heart Failure Research
Background
- Premature ventricular complex (PVC) induced cardiomyopathy (PVC-CMP) and left ventricular systolic dysfunction (LVSD) are clinically significant.
- Precise risk factors for these conditions remain unclear, necessitating further investigation.
Purpose Of The Study
- To systematically review and identify independent risk factors for PVC-CMP.
- To identify factors associated with left ventricular systolic dysfunction reversibility after PVC ablation.
Main Methods
- A systematic literature review was conducted across major databases (PubMed, EMBASE, Web of Science, CBM).
- Included observational studies were analyzed to calculate pooled odds ratios (OR) and 95% confidence intervals (CI) for identified parameters.
Main Results
- Three independent risk factors for PVC-CMP were identified: asymptomatic status (OR: 3.04), interpolation (OR: 2.47), and epicardial origin (OR: 3.04).
- Factors correlated with post-ablation LVSD reversibility included sinus QRS duration (OR: 0.95) and PVC burden (OR: 1.09).
Conclusions
- Asymptomatic status, interpolation, and epicardial origin are significant risk factors for PVC-CMP.
- Sinus QRS duration and PVC burden are key factors influencing the reversibility of LVSD post-ablation.
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