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Cell Migration

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.

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Related Experiment Video

Updated: Jun 24, 2026

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Published on: November 8, 2011

EZB-type diffuse large B-cell lymphoma cell lines have superior migration capabilities compared to MCD-type.

Marwa Sherif¹, Hendrik Schäfer¹, Sonja Scharf¹

¹Dr. Senckenberg Institute of Pathology, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.

British Journal of Haematology

|October 2, 2024

Summary

This summary is machine-generated.

Diffuse large B-cell lymphoma (DLBCL) subtypes show different migration abilities. EZB-type DLBCL cells migrate faster and overcome constrictions better than MCD-type, potentially due to nuclear stiffness differences.

Keywords:

diffuse large B‐cell lymphoma microchannel migration

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Last Updated: Jun 24, 2026

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

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Published on: November 8, 2011

A Simple Red Blood Cell Lysis Method for the Establishment of B Lymphoblastoid Cell Lines

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Published on: January 14, 2017

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

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Published on: March 30, 2018

Area of Science:

Hematology
Cell Biology
Oncology

Background:

Diffuse large B-cell lymphoma (DLBCL) is a common, aggressive B-cell cancer with variable patient outcomes.
Prognostic stratification of DLBCL patients is challenging due to tumor heterogeneity.
Recent identification of distinct genetic subtypes offers new avenues for understanding DLBCL biology.

Purpose of the Study:

To investigate whether different genetic subtypes of DLBCL exhibit distinct cell migration capabilities.
To explore the relationship between DLBCL genetic subtypes and their motility.
To identify potential mechanisms underlying differential cell migration in DLBCL.

Main Methods:

Utilized MCD- and EZB-type DLBCL cell lines for migration assays.
Assessed basal migration velocity in microchannels and ability to navigate 2 μm constrictions.
Performed live cell imaging on native human DLBCL tissue.
Quantified nuclear lamin A/C levels in different DLBCL subtypes.

Main Results:

EZB-type DLBCL cell lines demonstrated significantly higher basal migration velocity.
EZB-type DLBCL cells showed superior ability to pass through tight constrictions.
Similar migration trends were observed in live imaging of human DLBCL tissue.
MCD-type DLBCL exhibited elevated levels of nuclear lamin A/C, suggesting increased nuclear stiffness.

Conclusions:

Genetic subtypes of DLBCL possess differential migratory potentials.
Nuclear lamin A/C levels may contribute to the observed variations in cell motility between DLBCL subtypes.
Tumor cell motility could be an important factor influencing DLBCL prognosis and therapeutic response.