Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

India's 2021 differentiated TB care guidance: Is it feasible to implement and act upon?

The Indian journal of tuberculosis·2025
Same author

Methods of Brain Extraction from Magnetic Resonance Images of Human Head: A Review.

Critical reviews in biomedical engineering·2023
Same author

Olfactory abnormalities in temporal lobe epilepsy.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2015
Same author

Modulating effect of Leptadenia reticulata (Retz) Wight & arn against chromate (VI)-induced immunosuppression and oxidative stress on mouse splenic lymphocytes and bone marrow derived macrophages.

Journal of ethnopharmacology·2010

Related Experiment Video

Updated: Jun 11, 2025

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics
09:54

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics

Published on: September 10, 2018

7.4K

Optimizing Microfluidic Channel Design with High-Performance Materials for Safe Neonatal Drug Delivery.

T Archana1, N Nachammai1, S Praveenkumar2

  • 1Department of Electronics and Instrumentation Engineering, Annamalai University, Annamalai Nagar, Chidambaram, India.

Recent Advances in Drug Delivery and Formulation
|October 2, 2024
PubMed
Summary
This summary is machine-generated.

This study evaluated materials and microfluidic channel designs for neonatal drug delivery, finding PDMS to be a feasible solution. Optimized designs enhance drug delivery efficiency and safety for neonates.

Keywords:
Microchannel geometriesMicrofluidic devices.consistent administrationdrug flow ratesintravenous therapiesneonatal patients

More Related Videos

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

21.0K
High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
07:51

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

7.4K

Related Experiment Videos

Last Updated: Jun 11, 2025

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics
09:54

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics

Published on: September 10, 2018

7.4K
Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

21.0K
High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
07:51

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

7.4K

Area of Science:

  • Biomedical Engineering
  • Materials Science

Background:

  • Designing microfluidic channels for neonatal drug delivery demands careful consideration of efficiency and safety.
  • Optimizing material selection and channel geometry is crucial for effective neonatal drug administration.

Purpose of the Study:

  • To evaluate high-performance materials for microfluidic neonatal drug delivery.
  • To optimize microfluidic channel design through modeling and simulation for a target flow rate of 0.3-1 mL/hr.

Main Methods:

  • Materials evaluated included PDMS, glass, COC, PMMA, PC, TPE, and hydrogels.
  • COMSOL Multiphysics was used for simulation, analyzing fluid behavior in various channel geometries.
  • Material assessment focused on biocompatibility (ISO 10993), mechanical properties, chemical resistance, and ease of fabrication.

Main Results:

  • PDMS demonstrated flexibility and ease of simulation.
  • Optimized channel designs derived from COMSOL simulations showed improved efficiency.
  • PDMS emerged as a feasible material for neonatal drug delivery applications.

Conclusions:

  • This comparative study guides material and design selection for safer, enhanced neonatal microfluidic drug delivery.
  • The findings support the development of reliable drug delivery systems for neonates.