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Are Women's Breast Cancer Risk Appraisals in Line with Updated Clinical Risk Estimates Communicated? Results from a
Victoria G Woof1, Anthony Howell1,2, Lynne Fox2
1University of Manchester, Manchester, United Kingdom.
Summary
Women accurately updated their breast cancer risk perceptions after receiving new information, including breast density and polygenic risk score (PRS) data. This suggests risk communication strategies can effectively change personal risk appraisals.
Area of Science:
- Oncology
- Genetics
- Risk Assessment
Background:
- Breast cancer risk prediction models increasingly incorporate factors like breast density and polygenic risk scores (PRS).
- Previous studies indicate risk communication often fails to alter personal risk appraisals.
- This study investigates how women's risk perceptions change after receiving updated breast cancer risk estimates.
Purpose of the Study:
- To examine how women appraise their breast cancer risk after receiving updated risk estimates.
- To assess the integration of new risk factors (breast density, PRS) into women's risk perceptions.
- To evaluate the impact of risk communication strategies on risk appraisal.
Main Methods:
- 323 women received updated breast cancer risk estimates in a family history risk study.
- A subset of 190 women completed questionnaires on subjective risk, satisfaction, and worry.
- Risk notifications included decreased, increased, or unchanged risk categories.
Main Results:
- Women's subjective risk appraisals aligned with updated estimates.
- Age, PRS, and breast density significantly influenced risk appraisals.
- Those with increased risk notifications reported higher subjective risk perceptions.
Conclusions:
- Subjective breast cancer risk appraisals are modifiable with updated risk feedback.
- New information, including breast density and PRS, was integrated into risk appraisals.
- Effective communication strategies may enhance the acceptance of updated risk information.
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