Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Catabolism of extracellular glutathione supplies cysteine to support tumours.

Nature·2026
Same author

Microglial fructose metabolism is essential for glioblastoma growth.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Mitochondrial one-carbon metabolism is required for TGF-β-induced glycine synthesis and fibrotic responses.

Nature communications·2025
Same author

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes.

EMBO reports·2025
Same author

Tumour interstitial fluid-enriched phosphoethanolamine suppresses T cell function.

Nature cell biology·2025
Same author

Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jun 11, 2025

Assessment of the Metabolic Profile of Primary Leukemia Cells
06:21

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

10.4K

Identifying metabolic limitations in the tumor microenvironment.

Guillaume Cognet1, Alexander Muir1

  • 1Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA.

Science Advances
|October 2, 2024
PubMed
Summary

Solid tumors often face nutrient deprivation due to poor blood flow, causing metabolic stress. New methods reveal these limitations, impacting tumor growth and treatment effectiveness.

More Related Videos

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

17.9K
Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry
11:39

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

Published on: June 9, 2019

9.0K

Related Experiment Videos

Last Updated: Jun 11, 2025

Assessment of the Metabolic Profile of Primary Leukemia Cells
06:21

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

10.4K
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

17.9K
Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry
11:39

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

Published on: June 9, 2019

9.0K

Area of Science:

  • Oncology
  • Tumor Microenvironment
  • Cancer Metabolism

Background:

  • Solid tumors exhibit dysfunctional vasculature, impairing nutrient and oxygen delivery.
  • High tumor metabolic demands exacerbate nutrient scarcity, leading to metabolic stress.
  • Metabolic stress influences tumor progression and therapeutic responses.

Purpose of the Study:

  • To review experimental tools for identifying nutrient limitations in tumors.
  • To present the current understanding of tumor metabolic stress based on recent findings.

Main Methods:

  • Discussion of recently developed techniques for identifying limiting nutrients.
  • Analysis of studies utilizing these new approaches to assess tumor metabolism.

Main Results:

  • Emerging evidence highlights significant metabolic limitations in various solid tumors.
  • These limitations are driven by restricted availability of key nutrients like glucose and oxygen.

Conclusions:

  • Understanding tumor metabolic stress is crucial for developing effective cancer therapies.
  • Advanced techniques are providing unprecedented insights into the metabolic landscape of solid tumors.