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Orbit symmetry breaking in MXene implements enhanced soft bioelectronic implants
Yizhang Wu1, Yuan Li2, Yihan Liu1
1Department of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Science Advances
|October 2, 2024
Summary
Researchers developed a novel bioelectronic material, OBXene, to improve implantable device performance. This material significantly reduces bioelectronic-tissue impedance, enhancing signal recording and therapeutic interventions for better cardiac monitoring and treatment.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Bioelectronic implants offer revolutionary potential for internal organ monitoring and therapy.
- High bioelectronic-tissue impedance limits the efficacy of current implantable devices.
- Developing materials with improved electrical performance and biocompatibility is crucial.
Purpose of the Study:
- To engineer a novel MXene-based material (OBXene) with reduced bioelectronic-tissue impedance.
- To investigate the mechanisms behind OBXene's enhanced electrical properties.
- To demonstrate the utility of OBXene in a cardiac patch for real-time monitoring and stimulation.
Main Methods:
- Deformation of MXene's orbital symmetry to create OBXene.
- Characterization of OBXene's low impedance and piezoelectric properties.
- Fabrication and implantation of an OBXene cardiac patch on rodent and porcine models.
Main Results:
- OBXene exhibited significantly low bioelectronic-tissue impedance due to out-of-plane charge transfer.
- Schottky-induced piezoelectricity in OBXene facilitated interlayered charge transport.
- The OBXene cardiac patch enabled wireless, battery-free, long-term epicardium mapping and pacing.
Conclusions:
- OBXene represents a promising material for advanced bioelectronic implants.
- Reduced impedance and enhanced charge transport improve device efficacy.
- OBXene cardiac patches offer a viable solution for real-time cardiac monitoring and closed-loop stimulation.
