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Acute Post-infectious Glomerulonephritis in Children Admitted to a Tertiary Care Hospital: A Descriptive

Mandira Shrestha1, Romila Chimoriya1, Amrit Dhungel1

  • 1Nepal Medical college and teaching hospital, Jorpati, Kathmandu, Nepal.

JNMA; Journal of the Nepal Medical Association
|October 2, 2024
PubMed

Insights

Acute post-infectious glomerulonephritis (APIGN) affects 4.05% of children in Nepal, with elevated Antistreptolysin O titers and low C3 complement levels common. This highlights the need for continued APIGN surveillance and management in pediatric populations.

Area of Science:

  • Pediatric Nephrology
  • Infectious Diseases
  • Epidemiology

Background:

  • Post-infectious glomerulonephritis (APIGN) is a leading cause of pediatric hospital admissions in developing nations.
  • Understanding the local prevalence and clinical characteristics of APIGN is crucial for effective healthcare planning.

Purpose of the Study:

  • To determine the prevalence of APIGN in children admitted to a tertiary care hospital in Nepal.
  • To investigate the clinical profile, biochemical changes, and complications associated with APIGN in this pediatric cohort.

Main Methods:

  • A descriptive cross-sectional study was conducted from May 2020 to May 2023.
  • A census sample of 1554 children was analyzed, collecting socio-demographic, clinical, and laboratory data.
  • Data were analyzed using SPSS, presenting results as frequencies and percentages.

Main Results:

  • The prevalence of APIGN was 4.05% (63 out of 1554 children).
  • The mean age of affected children was 9.06 ± 3.48 years.
  • Elevated Antistreptolysin O titers were found in 54% of patients, and low serum C3 levels in 61.90%.

Conclusions:

  • APIGN represents a significant pediatric health concern in Nepal.
  • The findings underscore the necessity for sustained surveillance, targeted prevention efforts, and robust management strategies for APIGN in children.
Abstract

Keywords:
childrenedemahypertensionpostinfectious glomerulonephritis poststreptococcus glomerulonephritis.

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