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A simple and efficient method for separation of 99mTc from 100Mo targets
Desheng Chen1, Qinggang Huang1, Shiwei Cao1
1Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou, 516000, China; Gansu Isotope Laboratory, Lanzhou, 730000, China.
Summary
A new method efficiently separates technetium-99m (99mTc) from molybdenum-100 (100Mo) targets. This process yields high-purity 99mTc quickly, with minimal waste and high target recovery.
Area of Science:
- Nuclear Medicine
- Radiochemistry
- Materials Science
Background:
- Technetium-99m (99mTc) is a critical medical isotope facing supply challenges.
- Reliable production methods are essential for nuclear medicine applications.
Purpose of the Study:
- To develop a simple and efficient method for producing 99mTc from 100Mo.
- To optimize the separation and recovery process for 99mTc production.
Main Methods:
- Accelerator irradiation of 100Mo targets.
- High-temperature conversion of molybdenum targets.
- Selective dissolution of 99mTc using normal saline.
- Recovery of the 100Mo target material.
Main Results:
- Highly pure 99mTc separated within 1.5 hours.
- Separation efficiency exceeded 80%.
- Minimal radioactive waste generated due to reduced reagent use.
- Target material recovery rate over 95%.
Conclusions:
- The developed method offers a simple, efficient, and cost-effective approach for 99mTc production.
- This technique addresses supply concerns by enabling rapid separation and high yields.
- The process minimizes waste and maximizes resource recovery, making it environmentally favorable.
