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Related Experiment Video

Updated: Jun 11, 2025

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

Siglecs as modulators of macrophage phenotype and function.

Emily N Kukan¹, Gabrielle L Fabiano¹, Brian A Cobb¹

¹Case Western Reserve University School of Medicine, 10900 Euclid Ave., Cleveland, OH 44106, United States.

Seminars in Immunology

|October 2, 2024

Summary

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are immune receptors recognizing cell surface glycans. This review details Siglec expression in macrophages, exploring their functional roles and clinical relevance.

Keywords:

Immune checkpoint Macrophage Sialic acid Siglec

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Last Updated: Jun 11, 2025

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Depletion and Reconstitution of Macrophages in Mice

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Published on: August 1, 2012

Area of Science:

Immunology
Glycobiology
Cell Biology

Background:

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are key regulators of immune cell function.
These receptors bind terminal sialic acids on glycans, mediating diverse cellular responses.
Macrophages, a diverse immune cell population, express various Siglec members.

Purpose of the Study:

To review the expression patterns of Siglecs on macrophages.
To elucidate the functional significance of Siglec-glycan interactions in macrophages.
To explore the potential clinical applications of targeting Siglecs in macrophages.

Main Methods:

Literature review of Siglec expression and function in macrophages.
Analysis of glycan-binding specificities of different Siglec family members.
Integration of data on macrophage heterogeneity and Siglec involvement.

Main Results:

Macrophages express a range of Siglecs with distinct glycan specificities.
Siglec engagement influences macrophage phenotype, polarization, and effector functions.
Differential Siglec expression contributes to macrophage functional diversity.

Conclusions:

Siglecs play a critical role in modulating macrophage responses.
Understanding Siglec-macrophage interactions offers therapeutic opportunities.
Targeting Siglecs may provide novel strategies for immune-related diseases.