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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Phosphoproteomic Subtyping Of Gastric Cancer Reveals Dynamic Transformation With Chemotherapy And Guides Targeted Cancer Treatment.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Phosphoproteomic Subtyping Of Gastric Cancer Reveals Dynamic Transformation With Chemotherapy And Guides Targeted Cancer Treatment.

Related Experiment Video

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
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Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

634

Phosphoproteomic subtyping of gastric cancer reveals dynamic transformation with chemotherapy and guides targeted cancer treatment.

Hirokazu Shoji1, Hidekazu Hirano2, Yosui Nojima3

  • 1Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo 104-0045, Japan.

Cell Reports
|October 2, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Researchers identified three gastric cancer subtypes using deep phosphoproteome analysis. They observed dynamic cellular transitions and propose targeting AXL for advanced gastric cancer (AGC) treatment.

Keywords:
AXLCP: CancerEMTendoscopic biopsy

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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

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Area of Science:

  • Oncology
  • Molecular Biology
  • Proteomics

Background:

  • Advanced gastric cancer (AGC) has a poor prognosis with limited targeted treatment options.
  • Effective molecular targeted agents for unresectable or recurrent AGC are scarce.
  • Deep phosphoproteome analysis of minute biopsy samples is an emerging technique.

Purpose of the Study:

  • To investigate intracellular signaling pathways in advanced gastric cancer.
  • To identify distinct molecular subtypes of AGC based on phosphoproteomic profiles.
  • To explore the role of epithelial-mesenchymal transition (EMT) in AGC progression and identify potential therapeutic targets.

Main Methods:

  • Deep phosphoproteome analysis of 127 fresh-frozen endoscopic biopsy samples from untreated AGC patients.
gastric cancer
gilteritinib
phosphorylation signal
proteome
serial biopsy analysis
  • Serial biopsy analysis to track dynamic cellular changes during treatment.
  • Investigation of intracellular signaling networks, focusing on the kinome and EMT.

    • Main Results:

    • Identification of three distinct AGC subtypes based on cellular signaling status.
    • Observation of dynamic mesenchymal transitions and kinome rewiring during treatment.
    • Demonstration of conversion to an epithelial-mesenchymal transition (EMT) subtype throughout therapy.

    Conclusions:

    • Gastric cancer exhibits dynamic signaling pathway alterations, including EMT, during treatment.
    • Targeting the AXL pathway presents a potential therapeutic strategy for AGC.
    • The study provides valuable data for developing novel AGC treatments and biomarkers.