Related Experiment Video

Updated: Jun 11, 2025

Extraction of Extracellular Vesicles from Whole Tissue
09:03

Extraction of Extracellular Vesicles from Whole Tissue

Published on: February 7, 2019

15.0K

Communicating across distances - Biological functions of extracellular vesicles

Aila Akosua Kattner1

  • 1Freelance Journalist, Berlin, Germany.

Biomedical Journal
|October 2, 2024
PubMed

Insights

Extracellular vesicles (EVs) are crucial in neurological diseases, viral infections, and organ transplantation. This issue explores their roles, Parkinson's disease mechanisms, and diagnostic biomarkers.

Area of Science:

  • Biomedical science
  • Cell biology
  • Immunology

Background:

  • This issue highlights recent advancements in understanding extracellular vesicles (EVs) and their multifaceted roles.
  • Key research areas include EVs in neurological disorders, viral pathogenesis, and immune responses like trogocytosis and allogeneic transplantation.

Discussion:

  • The journal delves into the specific mechanisms of Parkinson's disease, emphasizing white matter involvement and exosome functions.
  • It also addresses polyomavirus-mediated damage in renal transplants and explores neural gating mechanisms and brain wave dynamics.

Key Insights:

  • A proposed miRNA signature offers potential as a diagnostic biomarker for Kawasaki disease.
  • The complex interplay between gut microbiota and the efficacy of immune checkpoint inhibitors is further elucidated.

Outlook:

  • Future research directions include refining EV biodistribution studies and understanding their therapeutic potential.
  • The critical need for therapeutic drug monitoring in clinical practice is reinforced.
Keywords:
AllograftExtracellular vesicleKawasaki diseaseParkinson's diseasePolyomavirus

More Related Videos

Isolation and Analysis of Traceable and Functionalized Extracellular Vesicles from the Plasma and Solid Tissues09:57

Isolation and Analysis of Traceable and Functionalized Extracellular Vesicles from the Plasma and Solid Tissues

Published on: October 17, 2022

2.0K
Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment10:09

Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment

Published on: June 2, 2020

6.8K

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K
Types of Signaling Molecules01:32

Types of Signaling Molecules

In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
10.2K
Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
8.5K
Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis01:18

Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

Vesicular transport is a cellular process that encompasses the engulfment of particles or dissolved substances by cells. It involves endocytosis, transcytosis, and exocytosis.
Endocytosis is a cellular mechanism that involves the inward folding of the cell membrane to create vesicles that capture and transport large drug molecules. This process comprises two distinct methods: pinocytosis (often referred to as "cell drinking") and phagocytosis (often referred to as "cell...
957
Exocytosis00:51

Exocytosis

Exocytosis is used to release material from cells. Like other bulk transport mechanisms, exocytosis requires energy.
66.3K
What is Cell Signaling?02:03

What is Cell Signaling?

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
116.1K