Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating immune complexes in pulmonary tuberculosis.

M D Ashtekar, A M Samuel

    Journal of Clinical & Laboratory Immunology
    |October 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Missing data may lead to changes in hip fracture database studies: a study of the American College of Surgeons National Surgical Quality Improvement Program.

    The bone & joint journal·2018
    Same author

    Surgery for a fracture of the hip within 24 hours of admission is independently associated with reduced short-term post-operative complications.

    The bone & joint journal·2017
    Same author

    Do we really know our patient population in database research? A comparison of the femoral shaft fracture patient populations in three commonly used national databases.

    The bone & joint journal·2016
    Same author

    General versus spinal anaesthesia for patients aged 70 years and older with a fracture of the hip.

    The bone & joint journal·2015
    Same author

    Mycobacterium tuberculosis 38kDa antigen and its encoding gene-experience in diagnostic applications.

    Indian journal of clinical biochemistry : IJCB·2012
    Same author

    PET/CT in pediatric oncology.

    Indian journal of cancer·2010
    Same journal

    Policy and science of FMD control: the stakeholders' contribution to decision making. A call for integrated animal disease management.

    Journal of clinical & laboratory immunology·2006
    Same journal

    An informative case of Graves' disease with implications for schizophrenia.

    Journal of clinical & laboratory immunology·2006
    Same journal

    Increase of circulating CD8+CD57+ lymphocytes after measles infection but not after measles vaccination.

    Journal of clinical & laboratory immunology·2006
    Same journal

    Review: immunomodulatory activity of pregnancy-associated plasma protein-A.

    Journal of clinical & laboratory immunology·2004
    Same journal

    Antibodies to Acinetobacter bacteria and bovine brain peptides, measured in bovine spongiform encephalopathy (BSE) in an attempt to develop an ante-mortem test.

    Journal of clinical & laboratory immunology·2004
    Same journal

    Principles of autoimmune disease: pathogenesis, genetics and specific immunotherapy.

    Journal of clinical & laboratory immunology·2004
    See all related articles

    Circulating immune complexes (CIC) are present in tuberculosis patients, with higher levels in sputum-positive cases. Treatment did not alter CIC levels, indicating their potential as biomarkers for disease activity.

    Area of Science:

    • Immunology
    • Infectious Diseases
    • Biochemistry

    Background:

    • Circulating immune complexes (CIC) are implicated in various inflammatory and infectious diseases.
    • Pulmonary tuberculosis (TB) is a significant global health challenge requiring improved diagnostic and prognostic markers.

    Purpose of the Study:

    • To investigate the presence and levels of CIC in patients with pulmonary tuberculosis.
    • To correlate CIC levels with disease activity and treatment response.

    Main Methods:

    • Detection of CIC using latex agglutination, PEG precipitation (OD at 280 nm), and radioimmunoassay (RIA).
    • Analysis of 100 TB patient sera and 40 normal control sera.
    • Correlation of CIC levels with sputum positivity and immunoglobulin classes (IgG, IgA, IgM).

    Related Experiment Videos

    Main Results:

    • 12% of patients were positive for CIC by all three methods; 13% were negative by all methods.
    • Higher CIC levels were observed in sputum-positive TB patients compared to sputum-negative patients.
    • IgM was detected in CIC of TB patients but not in controls, while IgG and IgA were present in both.

    Conclusions:

    • CIC detection is a valuable tool for assessing TB disease activity.
    • The presence of IgM in CIC may be specific to TB patients.
    • Antitubercular treatment did not significantly alter CIC levels, suggesting their persistence regardless of therapy.