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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
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[New drugs for the treatment of primary immune thrombocytopenia]

Hirokazu Kashiwagi1,2

  • 1Osaka Red Cross Blood Center.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 2, 2024
PubMed

Two thrombopoietin receptor agonists (eltrombopag and romiplostim), rituximab or splenectomy have been recommended for the treatment of glucocorticoid-resistant ITP in Japanese guidelines. In addition, the Syk inhibitor fostamatinib and FcRn inhibitor efgartigimod were approved in Japan for refractory ITP in 2023 and 2024, respectively. Clinical trials have also reported promising results for the new thrombopoietin receptor agonist avatrombopag, the BTK inhibitor rilzabrutinib, and the C1s inhibitor sutimlimab. These developments will usher in a new era in the treatment of ITP.

Keywords:
AvatrombopagEfgartigimodFostamatinibRilzabrutinib

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