Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

12.1K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
12.1K
Mitochondria01:37

Mitochondria

11.4K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
11.4K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
Mitochondrial Membranes01:45

Mitochondrial Membranes

9.1K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
9.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD4/CD8 ratio is associated with structural reorganization of vaccine-induced immune responses in people living with HIV.

Frontiers in immunology·2026
Same author

SARS-CoV-2 Surface Contamination and Viable Virus in High-Ventilation Single Rooms: Implications for Fomite Transmission.

Juntendo medical journal·2026
Same author

Isolation and identification of <i>Pseudoxanthomonas winnipegensis</i> from blood culture by MALDI-MS.

Frontiers in cellular and infection microbiology·2026
Same author

A STAT3 degrader demonstrates efficacy in venetoclax resistant acute myeloid leukemia.

Leukemia·2026
Same author

Species Distribution and Antifungal Susceptibility of Fungal Blood Isolates over a 16-Year Period at a University Hospital.

Medical mycology journal·2025
Same author

Enhancing monoclonal antibody diversity by integrating bulk sorting and machine learning.

Biochemistry and biophysics reports·2025

Related Experiment Video

Updated: Jun 11, 2025

Assessment of the Metabolic Profile of Primary Leukemia Cells
06:21

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

10.4K

[Mitochondrial metabolism in AML cells].

Yoko Tabe1

  • 1Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 2, 2024
PubMed
Summary

Mitochondria are key to acute myeloid leukemia (AML) survival and drug resistance. Targeting mitochondrial metabolism offers a promising strategy to overcome chemotherapy resistance and prevent AML relapse.

Keywords:
Acute myeloid leukemiaMetabolismMitochondriaOxidative phosphorylation

More Related Videos

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines
07:49

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines

Published on: March 17, 2023

2.3K
Assessment of Mitochondrial Oxygen Consumption Using a Plate Reader-based Fluorescent Assay
03:57

Assessment of Mitochondrial Oxygen Consumption Using a Plate Reader-based Fluorescent Assay

Published on: April 12, 2024

544

Related Experiment Videos

Last Updated: Jun 11, 2025

Assessment of the Metabolic Profile of Primary Leukemia Cells
06:21

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

10.4K
Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines
07:49

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines

Published on: March 17, 2023

2.3K
Assessment of Mitochondrial Oxygen Consumption Using a Plate Reader-based Fluorescent Assay
03:57

Assessment of Mitochondrial Oxygen Consumption Using a Plate Reader-based Fluorescent Assay

Published on: April 12, 2024

544

Area of Science:

  • Biochemistry
  • Oncology
  • Cell Biology

Background:

  • Mitochondrial metabolic dependencies are crucial in acute myeloid leukemia (AML), regulating gene expression, differentiation, and stemness.
  • These adaptations occur independently of genomic mutations and contribute to chemotherapy resistance and disease relapse.
  • AML cells exhibit metabolic vulnerabilities linked to oxidative phosphorylation, fatty acid oxidation, reactive oxygen species (ROS), and mitochondrial dynamics.

Purpose of the Study:

  • To review recent findings on targeting mitochondrial metabolism in AML.
  • To explore the efficacy of mitochondria-targeted agents in preclinical and clinical trials.
  • To assess the potential of these agents in combination with standard chemotherapies.

Main Methods:

  • Review of preclinical studies and clinical trials on mitochondria-targeted agents.
  • Analysis of research focusing on AML cell metabolism, signal transduction, respiration, ROS generation, and mitophagy.
  • Investigation of mitochondrial properties in AML and leukemia stem cells.

Main Results:

  • Mitochondrial metabolic adaptations are characteristic of AML and influence its progression.
  • Targeting mitochondrial pathways presents a metabolic vulnerability in AML cells.
  • Mitochondria-targeted agents show promise in clinical trials, particularly in combination therapies.

Conclusions:

  • Mitochondrial metabolism is a critical determinant of AML behavior and therapeutic response.
  • Targeting mitochondria represents a viable strategy to overcome chemotherapy resistance and improve outcomes in AML.
  • Further investigation into mitochondria-targeted agents and combination therapies is warranted for AML treatment.