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Updated: May 12, 2026

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Published on: August 16, 2012

A Thin Polymer Layer Enables Peptide-Polycation Complexes with Ultrahigh Efficient Encapsulation.

Guangfei Wei^1,2, Bin Zong^1,2, Quan He^1,2

¹Clinical Medical Research Center, Zhenjiang Hospital of Chinese Traditional and Western Medicine, Zhenjiang, 212004, China.

Small (Weinheim an Der Bergstrasse, Germany)

|October 3, 2024

Summary

This summary is machine-generated.

Researchers developed a novel peptide nanoparticle encapsulation method for high drug loading. This technique achieves over 95% loading efficiency and stable core-shell structures for potential therapeutic applications.

Keywords:

core‐shell structure efficient encapsulation individual nanoparticle encapsulation peptide encapsulation surface decoration

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Assembly and Characterization of Polyelectrolyte Complex Micelles

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Last Updated: May 12, 2026

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

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Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

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Assembly and Characterization of Polyelectrolyte Complex Micelles

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Published on: March 2, 2020

Area of Science:

Nanotechnology
Materials Science
Biomedical Engineering

Background:

Immobilizing polymers on peptide nanoparticles for drug delivery remains a challenge.
Existing methods struggle with high drug loading efficiency and stability.

Purpose of the Study:

To develop a novel monolayer encapsulation strategy for peptide nanoparticles.
To achieve high drug loading efficiency and stable core-shell structures.
To evaluate the therapeutic potential of encapsulated insulin for type 1 diabetes.

Main Methods:

Surface adsorption and electrostatic interactions to form a peptide-polymer network.
Granulation of peptide molecules followed by aggregation with polymers.
Dissolution of surplus polymers in an aqueous phase to create a core-shell structure.

Main Results:

Achieved a superior drug loading degree of up to 95.4%.
Established a stable core-shell structure with over 90% peptide mass fraction under external force.
Developed insulin-polycation complex (InsNp@PEI) demonstrating reduced inflammation and effective glycemic control.

Conclusions:

The proposed single surface decoration strategy offers ultrahigh encapsulation efficiency for peptides.
This method enables the creation of stable, high-drug-loading nanoparticles.
The developed nanoparticle system shows promise for treating type 1 diabetes and other applications.