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Clozapine monitoring requirements: is it time for an update?

Emilio Fernandez-Egea1, Robert A McCutcheon2

  • 1Cambridgeshire and Peterborough NHS Foundation Trust and Department of Psychiatry, University of Cambridge, Cambridge, UK.

The British Journal of Psychiatry : the Journal of Mental Science
|October 3, 2024
PubMed

Oloyede and colleagues advocate for updating haematological monitoring requirements for clozapine, arguing that current protocols overestimate the risk of clozapine-induced agranulocytosis. Their research suggests that stringent monitoring may unnecessarily limit access to clozapine, a crucial treatment for resistant schizophrenia. The editorial supports calls for international consensus to carefully weigh the pros and cons of relaxing monitoring guidelines while ensuring comprehensive care for patients.

Keywords:
Treatment-resistant schizophreniaagranulocytosisclozapinehaematological monitoringpharmacovigilance

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