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Development of Immunocompetence01:22

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
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Pemphigus and Pregnancy.

Dipankar De1, Shikha Shah1, Rahul Mahajan1

  • 1Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Indian Dermatology Online Journal
|October 3, 2024
PubMed
Summary
This summary is machine-generated.

Pemphigus during pregnancy can worsen, particularly in the first two trimesters, potentially impacting both mother and fetus. Careful management and counseling are vital for women with this autoimmune condition.

Keywords:
Neonatal pemphiguspemphiguspregnancypregnancy outcome

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Area of Science:

  • Dermatology
  • Obstetrics
  • Immunology

Background:

  • Pemphigus is an autoimmune blistering disease.
  • Pregnancy can exacerbate autoimmune conditions like pemphigus due to immune system shifts.
  • Pemphigus in pregnancy presents unique challenges for maternal and fetal health.

Purpose of the Study:

  • To review the implications of pemphigus in pregnancy.
  • To discuss potential maternal and fetal outcomes.
  • To outline management strategies for pemphigus during gestation.

Main Methods:

  • Literature review of pemphigus in pregnancy.
  • Analysis of autoimmune disease pathophysiology during gestation.
  • Synthesis of clinical management guidelines.

Main Results:

  • Pemphigus often flares during pregnancy, especially in the first two trimesters.
  • Adverse fetal outcomes include stillbirth and neonatal pemphigus, resulting from transplacental antibody transfer.
  • Disease severity correlates with increased risk of adverse materno-fetal outcomes.

Conclusions:

  • Management requires individualized risk-benefit assessment of therapies.
  • Optimizing maternal and fetal health is paramount.
  • Pre-conception counseling is crucial for women with pemphigus planning pregnancy.