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Published on: May 4, 2021
Longitudinal associations between microRNAs and weight in the diabetes prevention program
Elena Flowers1,2, Benjamin Stroebel1, Kimberly A Lewis1
1Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, United States.
Frontiers in Endocrinology
|October 3, 2024
Summary
Circulating microRNAs are linked to weight changes over time. These microRNAs may offer insights into the causes of obesity and disease risk.
Area of Science:
- Biochemistry
- Genetics
- Metabolic Diseases
Background:
- Circulating microRNAs (miRNAs) are associated with overweight and obesity.
- Limited research distinguishes cross-sectional associations from prodromal risk markers.
Purpose of the Study:
- To assess longitudinal relationships between circulating miRNAs and weight.
- To investigate miRNA associations with weight changes in the Diabetes Prevention Program trial.
Main Methods:
- Analyzed plasma samples from 150 participants using a Fireplex Assay.
- Employed generalized linear mixed models and logistic regression for longitudinal analysis.
- Evaluated miRNA levels at baseline, year 1, and year 2 in relation to weight changes.
Main Results:
- Seven miRNAs (miR-126, miR-15a, miR-192, miR-23a, miR-27a) associated with weight over 2 years.
- MiR-197 and miR-320a remained significant after multiple comparisons.
- Baseline let-7f, miR-17, and miR-320c associated with 3% weight loss after 2 years.
Conclusions:
- Provided evidence for longitudinal relationships between circulating miRNAs and weight.
- Suggests miRNAs may offer insights into the etiology of overweight and obesity.
- Highlights the need for further research into miRNA biomarkers for weight management and disease prevention.
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